BREATH HOLDING FOR 20 S FOLLOWING EXTENDED EXPIRATION IS A PRACTICAL, EFFECTIVE AND ROBUST STANDARD WHEN MEASURING CEREBROVASCULAR REACTIVITY IN HEALTHY ADULTS USING BOLD FMRI AT 3 T

Background and Purpose: BOLD fMRI is becoming the preferred modality to study cerebrovascular reactivity.Amongst the vasoactive stimuli to induce it, breath holding is considered equal to other methods but both cerebrovascular reserve measures and breath holding designs lack standardization.We have systematically considered whether breath holding p

In silico trials recently emerged as a disruptive technology, which may reduce the costs related to the development and marketing approval of novel medical technologies, as well as shortening their time-to-market.In these trials, virtual patients are recruited from a large chiggate.com database and their response to the therapy, such as the implant

The posterior signalling centre (PSC), a small group of specialised cells, controls hemocyte (blood cell) homeostasis in the Drosophila larval hematopoietic organ, the lymph gland.This role of the PSC is very reminiscent of the "niche," the micro-environment of hematopoietic stem cells in vertebrates.We have recently shown that the PSC acts in a no

Nationalism in China emerged through historical experiences of greatness and humiliation.Until the 19th century, the Chinese were proud of its civilization and considered themselves as the centre of the world.Humiliation in the wars with Britain and Japan created new feelings of nationalism in China.The nature of the nationalism changed according t